Table 2.
Associations between metabolites (continuous) and risk of breast cancer, for metabolites with raw P values < 0.05
| Class | Metabolite | Odds ratio and 95% CI (for 1 SD)a | Raw P value | Permutation-based minP P valueb | Bonferroni P valuec | False discovery rate P valued |
|---|---|---|---|---|---|---|
| Amino acids | Arginine | 0.89 (0.80–0.99) | 0.035 | 0.753 | 1.000 | 0.166 |
| Asparagine | 0.87 (0.80–0.95) | 0.002 | 0.109 | 0.240 | 0.062 | |
| Glutamine | 0.91 (0.84–0.99) | 0.031 | 0.731 | 1.000 | 0.166 | |
| Glycine | 0.90 (0.83–0.97) | 0.005 | 0.229 | 0.629 | 0.090 | |
| Histidine | 0.91 (0.84–0.99) | 0.020 | 0.588 | 1.000 | 0.131 | |
| Lysine | 0.90 (0.83–0.98) | 0.010 | 0.389 | 1.000 | 0.102 | |
| Threonine | 0.92 (0.85–0.99) | 0.034 | 0.752 | 1.000 | 0.166 | |
| Acylcarnitines | C14:1 | 1.09 (1.01–1.18) | 0.028 | 0.704 | 1.000 | 0.166 |
| C18:1 | 1.11 (1.00–1.22) | 0.040 | 0.793 | 1.000 | 0.183 | |
| C2 | 1.15 (1.06–1.24) | 0.0004 | 0.031 | 0.051 | 0.036 | |
| Glycerophospholipids | PC aa C32:3 | 0.90 (0.82–0.99) | 0.026 | 0.674 | 1.000 | 0.166 |
| PC aa C36:2 | 0.89 (0.82–0.97) | 0.009 | 0.339 | 1.000 | 0.099 | |
| PC aa C36:3 | 0.89 (0.82–0.96) | 0.002 | 0.117 | 0.272 | 0.062 | |
| PC aa C38:3 | 0.92 (0.85–0.99) | 0.035 | 0.753 | 1.000 | 0.166 | |
| PC ae C34:2 | 0.90 (0.84–0.97) | 0.008 | 0.317 | 0.966 | 0.099 | |
| PC ae C36:2 | 0.90 (0.84–0.98) | 0.009 | 0.339 | 1.000 | 0.099 | |
| PC ae C36:3 | 0.88 (0.82–0.95) | 0.001 | 0.044 | 0.073 | 0.036 | |
| PC ae C38:2 | 0.88 (0.81–0.96) | 0.002 | 0.128 | 0.310 | 0.062 | |
| PC ae C38:3 | 0.90 (0.83–0.98) | 0.012 | 0.425 | 1.000 | 0.107 | |
| PC ae C38:5 | 0.93 (0.86–1.00) | 0.047 | 0.836 | 1.000 | 0.205 | |
| PC ae C40:1 | 0.92 (0.84–0.99) | 0.030 | 0.730 | 1.000 | 0.166 | |
| PC ae C40:4 | 0.91 (0.84–0.98) | 0.018 | 0.553 | 1.000 | 0.129 | |
| PC ae C42:1 | 0.90 (0.83–0.98) | 0.010 | 0.393 | 1.000 | 0.102 | |
| lysoPC a C18:0 | 0.88 (0.80–0.98) | 0.014 | 0.473 | 1.000 | 0.115 | |
| lysoPC a C18:2 | 0.89 (0.81–0.96) | 0.004 | 0.209 | 0.559 | 0.090 | |
| lysoPC a C20:3 | 0.90 (0.83–0.98) | 0.013 | 0.434 | 1.000 | 0.107 | |
| Sphingolipids | SM C20:2 | 0.90 (0.82–0.98) | 0.018 | 0.546 | 1.000 | 0.129 |
| SM (OH) C22:1 | 0.90 (0.83–0.97) | 0.008 | 0.322 | 1.000 | 0.099 | |
| Sugars | Hexose | 1.12 (1.01–1.24) | 0.035 | 0.752 | 1.000 | 0.166 |
SD standard deviation, CI confidence interval
Italicized text indicates a statistically significant association with breast cancer risk after adjustment of P values by permutation-based minP
aOdds ratios were estimated by logistic regression conditioned on center of recruitment, age, menopausal status at the time of blood collection, phase of the menstrual cycle at blood collection (for premenopausal women only), use of exogenous hormone at blood collection, time of the day at blood collection, and fasting status at blood collection
bMultiple testing controlled for family-wise error rate at α = 0.05 by permutation-based stepdown minP adjustment of P values
cMultiple testing controlled for family-wise error rate at α = 0.05 by Bonferroni adjustment of P values
dMultiple testing controlled for false discovery rate at α = 0.05