Table 5.
Median of pharmacokinetic parameters for mefloquine, chloroquine and lumefantrine in patients with homologous parasites by treatment outcome
| Mefloquine | Chloroquine | Lumefantrine | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Cure | Relapse | p-value | Cure | Relapse | p-value | Cure | Relapse | p-value | |
| N of patients | 53 | 6 | – | 52 | 7 | – | 52 | 7 | – |
| AUC(0–63 day) (µg/mL h) | |||||||||
| Per outcome | 338.6 | 302.0 | 0.67 | 105.9 | 95.8 | 1.0 | 7.3 | 3.73 | 0.96 |
| Overall | 338.6 [256.0–408.0] | – | 103.8 [83.0–126.3] | – | 6.7 [2.7–12.0] | – | |||
| Half-life (days) | |||||||||
| Per outcome | 17.7 | 25.6 | 0.58 | 18.5 | 19.3 | 0.42 | NA | NA | – |
| Overall | 17.8 [15.0–24.8] | – | 18.7 [15.4–27.8] | – | NA | – | |||
Overall values are median with 25–75 percentiles in square brackets and N = 59
NA non-applicable