Fig. 8.

TUFT1 promotes TNBC cell resistance to chemotherapy by upregulating the NF-κB pathway. a, b MDA-MB-231 cells were transfected with TUFT1-shRNA or scr-shRNA following treatment with various doses of doxorubicin and Taxotere for 24 h. Levels of p-p65, p65, XIAP, Survivin, c-caspase 3 and c-PARP1 were examined by western blotting in MDA-MB-231 cells (n = 3). Results are presented as mean ± SD. The statistical significance was assessed by Student’s t-test; *p < 0.05, **p < 0.01