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. 2019 Sep 23;10:291. doi: 10.1186/s13287-019-1385-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — A proposed model showing the mechanism of action of UC/PL-MSCs on TGF-β1-induced fibrogenic activation in human primary intestinal myofibroblasts. TGF-β1 induces expression of Procol1A1, FN, and α-SMA by activating the MRTF-A/SRF signaling and Smad2/3. UC/PL-MSCs inhibit TGF-β1-induced fibrogenic responses by blocking the RhoA/MRTF-A/SRF signaling and Smad2/3