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Oral administration of TSN protected Balb/c mice from influenza A virus-induced death. (A and B) TSN (1 mg/kg) was orally administered to Balb/c mice daily for 8 days before intranasal infection with mouse-adapted A/PR/8/34 at 5× LD50. The survival rate (A) and body weight (B) of uninfected mice (CON, n = 5), vehicle-treated infected mice (H1N1, n = 10), and TSN-pretreated infected mice (n = 10 at each dose, 1 mg/kg per day for 7 days) were monitored for 17 days.
