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Actions of ADP and AMP on rat P2X7 and rat P2X2 receptor channels. Current responses from oocytes expressing rat P2X7 to 1 mm ADP (A) and 10 mm AMP (B) before and after 500 μm ATP are shown. Current responses from oocytes expressing rat P2X2to 100 μm ADP (C) and 500 μm AMP (D) before and after 50 μm ATP are also shown. Right panels ofA–D, Relative amplitude (mean ± SEM) of ADP- and AMP-induced current during initial (1) and subsequent (2) application. *p < 0.05.
