Fig. 4.

Effect of MK-801 on sIPSCs from a layer III cell. In a layer III PCC/RSC pyramidal cell held at +30 mV, bath-applied MK-801 (40 μm) (B) decreased sIPSCs compared with control (A), an effect similar to that seen in layer V (Fig. 3). Recorded sIPSCs were abolished by BMI (20 μm) (C). Calibration: 500 msec, 0.1 nA. D, Camera lucida reconstruction of the same cell. As shown, this is also a pyramidal cell, with processes slightly different from the cell shown in Figure 3, although the pharmacological responses to MK-801 were similar. I–VI, Cortical lamina. Arrows denote axon. Scale bar, 100 μm.