Fig. 11.

Influence of U0126 on the induction of pERK in hippocampus. Saline or U0126 was infused 20 min before infusion of BDNF (0.25 μg) into the dentate gyrus. Phospho-ERK immunolabeling was determined at the time points indicated. Arrows indicate the sites of infusion. Representative sections are shown for each time point and condition. The locations of the dentate gyrus (DG) and CA3 and CA1 pyramidal cell layers (PyrCL) are indicated. Similar effects were observed in three or four separate animals for each condition.