Fig. 4.

Infusion of BDNF into the hippocampus has an antidepressant effect in the FST. BDNF, NT-3, NGF, or saline (SAL) was infused into the dentate gyrus or CA3 as indicated. Three days later, the durations of immobility, swimming, and climbing in the FST were determined. The results are divided into two 5 min time blocks as indicated and are the mean ± SEM of thenumber of animals indicated under eachcolumn. *p < 0.05; **p < 0.01; ***p < 0.001 when compared with the corresponding saline-injected controls (ANOVA and Scheffe's test). Left top, Immobility time, 0–5 min,F_(3,49) = 16.348; p< 0.0001; immobility time, 6–10 min,F_(3,49) = 15.823; p< 0.0001; left middle, swimming time, 0–5 min,F_(3,49) = 4.997; p= 0.0042; swimming time, 6–10 min,F_(3,49) = 18.025; p< 0.0001; left bottom, climbing time, 0–5 min,F_(3,49) = 1.807; p= 0.1582; climbing time, 6–10 min,F_(3,49) = 0.477; p= 0.7001; right top, immobility time, 0–5 min,F_(2,30) = 15.749; p< 0.0001; immobility time, 6–10 min,F_(2,30) = 8.219; p= 0.0014; right middle, swimming time, 0–5 min,F_(2,30) = 6.811; p= 0.0036; swimming time, 6–10 min,F_(2,30) = 10.129; p= 0.0004; right bottom, climbing time, 0–5 min,F_(2,30) = 1.243; p= 0.3031; climbing time, 6–10 min,F_(2,30) = 0.812; p= 0.4536. There were no significant treatment × time interactions.