Influence of neurotrophic factor infusion into the hippocampus on locomotor activity. BDNF, NT-3, NGF, or saline (SAL) was infused into the dentate gyrus or CA3, and 3 d later the times in center, distance, and velocity in an open field were determined. The results are the mean ± SEM of thenumber of animals indicated under eachcolumn. Left top, Time in the center,F(3,30) = 1.285; p= 0.2973; left middle, distance,F(3,30) = 1.143; p= 0.3479; left bottom, velocity,F(3,30) = 1.129; p= 0.3529; right top, time in the center,F(2,15) = 0.073; p= 0.9295; right middle, distance,F(2,15) = 0.650; p= 0.5359; right bottom, velocity,F(2,15) = 0.635; p= 0.5438.