Fig. 2.

Behavioral response of wild-type and CREB^αΔ mice to chronic antidepressant treatment. Animals were administered DMI (10.0 mg/kg, i.p.) twice daily with 20.0 mg/kg, subcutaneously administered on testing days and measured for immobility in the forced swimming test. CREB^αΔmutant mice administered saline had significantly lower immobility times than saline-treated wild type mice. DMI administration significantly reduced immobility times in both wild-type and CREB mutant mice on days 1 and 14 of the chronic treatment paradigm. Results are presented as mean immobility ± SEM (in seconds). ANOVA andpost hoc Newman–Keuls pairwise comparisons revealed the following differences: +p < 0.05 versus saline, corresponding gene and day; *p < 0.05 versus different gene, same treatment and day.