Fig. 3.
Behavioral response of wild-type and CREBαΔ mice in the TST to subchronic antidepressant treatment. Animals were administered saline, DMI, or FLX (20 mg/kg, i.p.) 30 min before a 6 min test session. Saline-treated CREBαΔ mutant mice demonstrated significantly lower immobility times than saline-treated wild-type mice. Subchronic FLX and DMI significantly reduced immobility times in both wild-type and CREBαΔ mutant mice compared with respective saline controls. Results are presented as mean immobility ± SEM (in seconds). ANOVA and post hoc Fisher's pairwise comparisons revealed the following differences: **p< 0.05 versus wild-type saline; ***p < 0.05 versus wild-type saline; +p < 0.05 versus wild-type fluoxetine; #p < 0.05 versus mutant saline (F(2,48) = 16.3); *p < 0.05 versus wild-type saline (F(1,48) = 3.8).