Fig. 3.

Examples of voltage dependence of the EPSC and its AMPA or NMDA component in the SC and PP inputs. A, The mixed EPSC (first and third columns) and the isolated AMPA EPSC (second andfourth columns) in the SC and PP inputs in the same cell. At −60 mV, the major fraction of the SC and PP EPSC area is attributable to the AMPA conductance. At +60 mV, most of the SC EPSC area is attributable to the NMDA, whereas most of the PP EPSC area is still attributable to the AMPA conductance. The isolated AMPA EPSC behaves similarly in both inputs with fairly close values of reversal potential. B, The mixed EPSC (first and third columns) and the isolated NMDA EPSC (second and fourth columns) in the SC and PP inputs in a similar cell (different from A). At −60 mV, the AMPA current determines EPSC area in both inputs. At +60 mV, the AMPA blockade does not affect the SC EPSC area but strongly decreases the PP EPSC area. Only 7 of 14 voltage points are shown. Each trace is an average of five. Calibration bars are shown in the middle right.