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. 2002 Feb 15;22(4):1238–1247. doi: 10.1523/JNEUROSCI.22-04-01238.2002

Fig. 6.

Fig. 6.

Inhibition of activities of the LT and HT channels by cytoskeleton disrupters, cytochalasin D, and colchicine.A, B, Example traces of the effect of cytochalasin D on activities of LT (A) and HT (B) MS channels. Negative pressures were applied to patch pipettes to activate the MS channels after forming cell-attached patches. The cell-attached patches were incubated with 10 μm cytochalasin D for ∼20 min. The negative pressures were repeated after the cytochalasin D application. C, Summaries of the effects of repeated applications of suction pressures on the pressure-activity relationships of LT (n = 4–6) and HT (n = 4–7) MS channels. Note that repeated applications of suction pressures do not change the overall responses of the MS channels to pressures. D, Summaries of the effects of 10 μm cytochalasin D on the pressure responses of LT (n = 4–6) and HT (n = 3–7) MS channels. E, Summaries of the effects of 500 μm colchicine on the pressure responses of LT (n = 4–5) and HT (n = 3–6) MS channels.