Fig. 4.

Disrupting CICR has no effect on delayed release at the parallel fiber to stellate cell synapse. Ai, Seventy consecutive traces before (top) and after (bottom) bath application of 10 μm ryanodine. Aii, Raster plot of quantal events, with the vertical bar indicating the time of ryanodine application. B, Average PSTH plots of quantal events before (solid line) and after (dashed line) 10 μm ryanodine (B, top;n = 4) or 10 μm thapsigargin (B, bottom; n = 4). PSTH plots for each experiment were made for 10 min periods in both control conditions and after 10 min drug application. These PSTH plots were then normalized with respect to the peak rate in control conditions. Normalized PSTH plots from the different experiments were then averaged.