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Disrupting CICR has no effect on the residual calcium signal at four excitatory synapses. A, At the PF synapse, peak ΔF/F signal (left) remains unchanged after bath application of 10 μm ryanodine (solid bar). Representativetraces (right) are superimposed averages of five trials before and after ryanodine application. Similar results were found using 10 μm ryanodine at the AC synapse (B), and 100 μm ryanodine at the MF (C) and CF (D) synapses.
