Fig. 7.

Cell-counting study of damaged neurons (A) and Western blot analyses of cytosolic cytochrome c and caspase-3 (B) in the caspase-3 inhibitor study. The number of damaged CA1 neurons was significantly smaller in the Z-DEVD-FMK-treated Wt group than in the vehicle-treated Wt group (n = 6 each), whereas no difference was observed in the Tg group (A). Z-DEVD-FMK did not affect cytosolic cytochrome c at 1 d but reduced procaspase-3 and active caspase-3 only in the Wt animals at 3 d (B). The data shown are representative of two independent studies. *p < 0.05. N, Non-ischemic; Veh, vehicle;DEVD, Z-DEVD-FMK.