Skip to main content
. 2002 May 15;22(10):4015–4024. doi: 10.1523/JNEUROSCI.22-10-04015.2002

Fig. 3.

Fig. 3.

The caspase-8 pathway is involved in HIV/gp120-induced neuronal apoptosis. A, Neutralizing antibody to TNF-α prevented gp120-induced apoptosis (*p < 0.001; n = 6 from 2 independent experiments). B, C, Specific inhibition of caspase-8 also prevented caspase-3 activation (*p < 0.02; n = 6 from 2 independent experiments) and apoptosis (*p < 0.001; n = 6 from 2 independent experiments) induced by exposure to gp120 for 24 hr. D, Caspase-8 was activated in neurons after exposure to gp120. Cultured neurons exposed to gp120 for 6 hr were fixed and double immunostained with anti-MAP-2 (green) antibody and anti-active caspase-8 (red; arrows). Caspase-8 was observed in the nuclei (red) and cytoplasm (yellow) of MAP-2-labeled neurons.