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Modulation of S942A dSlo by PKAc. Whole-cell dSlo currents were recorded from cells transfected with a dSlo mutant (S942A) alone (A) or S942A dSlo together with PKAc (B), using recording conditions identical to those described in Figure 1. Cotransfection of PKAc significantly decreases the peak S942A dSlo current density (mean ± SEM) (C) (p < 0.01) and increases the activation time constant (mean ± SEM) (D) (p < 0.01) at 165 mV.
