Fig. 7.
Dark-adapted ERG components that reflect bipolar cell output are altered in GABACρ1 null mice.A, Dark-adapted ERGs to the brightest flash stimulus, filtered to isolate the OPs, in eight WT and seven GABACρ1 null mice. In the filtered responses from every GABACρ1 null mouse, there were more OPs, and their amplitude was larger than the number and amplitude of the response in WT mice. B, Mean number of OP wavelets (± 1 SEM) as a function of stimulus intensity in WT (open bars) and in GABACρ1 null mice (filled bars). At all stimulus intensities, significantly more OPs are observed in responses of GABACρ1 null mice. C, Mean peak amplitude of each of the individual OPs from WT and GABACρ1 null mice elicited by the brightest flash (0.5 log cd sec/m2). Conventions are the same as inB. Note that OP5 is present in all GABACρ1 null mice but absent in all WT mice.