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Effects of a cannabinoid agonist, WIN55,212-2 (WIN), on EPSCs (A) and IPSCs (B, C). Amplitudes of EPSCs (A) and IPSCs (B, C) are plotted as a function of time. The bath was perfused with a solution containing 1–1000 nm WIN55,212-2 or a cannabinoid antagonist, AM281 (0.3 μm), for the periods indicated by thehorizontal lines. The traces of EPSCs (A) and IPSCs (B, C) acquired before and during application of WIN55,212-2 are superimposed (right).
