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. 2002 Oct 15;22(20):8797–8807. doi: 10.1523/JNEUROSCI.22-20-08797.2002

Fig. 7.

Fig. 7.

Role of α-synuclein in synaptic responses to repetitive stimulation. The slopes of field EPSPs during the entire recording were normalized to the first EPSP slope in each recording.A, Normal synaptic responses to a brief HFS (100 Hz, 40 pulses) at α-synuclein synapses. Representative recordings of entire EPSP traces from wild-type (WT) and knock-out (KO) hippocampus are shown in the inset.Stimulus artifacts were removed to clarify each EPSP waveform.B, Impaired responses to a PRS (300 stimuli at 12.5 Hz) in Snca−/− synapses. Time course of the effects of a stimulus train are shown. Representative single EPSPs at one-tenth (*) stimulus and one-hundredth (‡) stimulus are shown in the inset. Every five points of responses was averaged, and all EPSP slopes were normalized to the first EPSP slope.