Fig. 2.
CPG and HCA directly block the cystine–glutamate antiporter. The uptake of [35S]cystine in striatal tissue slices incubated was measured in the presence and absence of CPG, HCA, the group I mGluR antagonist AIDA, or NMDA (N = 4/drug). Data are presented as [35S]cystine uptake in the presence of inhibitors expressed as percentage of change of [35S]cystine uptake in the absence of inhibitors. A one-way ANOVA on [35S]cystine uptake indicated a significant effect of drug concentration for CPG (F(3,9) = 47.23; p < 0.05) and HCA (F(3,9) = 15.74; p< 0.05) . *p < 0.05, difference from [35S]cystine uptake in the absence of inhibitors (Fisher's LSD post hoc analysis).