Fig. 5.
Na+-dependent glutamate transporters shape the effect of glutamate released from the cystine–glutamate antiporter. In vivo microdialysis was used to sample extrasynaptic glutamate in the striatum before and after infusion of the broad spectrum Na+-dependent glutamate transport inhibitor TBOA alone (n = 6) or with the cystine–glutamate exchange inhibitor CPG (n = 6). A one-way ANOVA on glutamate levels indicated a significant effect of drug concentration for only TBOA alone (F(3,30) = 9.45;p < 0.05). *p < 0.05, difference from baseline (Fisher's LSD post hocanalysis).