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LVGCC inhibitors do not prevent acquisition of context fear. A, Experimental design (7–8 mice per group). B, Freezing shown in 2 min blocks during the entire 12 min session for mice injected with nifedipine (40 mg/kg, 50 min pretreatment) or vehicle. Unsignaled foot shocks occurred at the 2nd, 4th, 6th, 8th, and 10th minutes. C, Freezing 24 hr later during a 5 min drug-free context exposure. D,E, Identical experiment conducted with nimodipine (16 mg/kg, 20 min pretreatment).
