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Kaplan–Meier cumulative survival analysis of G93A SOD1 mice with or without MT-I and MT-II expression following the accelerated breeding protocol. Survival in G93A SOD1 mice is dependent on levels of MT-I and MT-II expression (log-rank test;p < 0.0001). MT−/−, MT-I and MT-II knock-outs; MT+/−, mice heterozygous for both MT-I and MT-II.
