Fig. 2.

Survival and onset of motor dysfunction is influenced by levels of MT-I and MT-II expression (prolonged breeding protocol). A, Kaplan–Meier cumulative survival analysis (log-rank test; p < 0.0001). B, Stride length analysis; onset of motor dysfunction is significantly influenced by non-neuronal metallothionein expression levels.C, Grip strength analysis; onset of motor dysfunction is significantly affected by non-neuronal metallothionein expression.MT−/−, MT-I and MT-II knock-outs; MT+/−, mice heterozygous for both MT-I and MT-II.