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Survival and disease course is influenced by MT-III expression. A, Kaplan–Meier cumulative survival analysis (log-rank test; p < 0.0001).B, Stride length analysis; progression but not onset of motor dysfunction is significantly affected by neuronal MT-III expression. C, Grip strength analysis; progression of motor dysfunction is significantly affected by neuronal MT-III expression. MT−/−, MT-III knock-outs;MT+/−, mice heterozygous for MT-III.
