Fig. 6.
Motor neuron loss is enhanced in G93A SOD1 mice lacking MT-III. A, L5–L6 ventral horn from a 5.25-month-old G93A SOD1 transgenic mouse with normal MT-III.B, L5–L6 ventral horn from a 5.25-month-old G93A SOD1 transgenic mouse lacking MT-III. Magnification, 400×.C, Motor neuron counts performed on L5–L6 spinal cords at various functional time points. Motor neuron survival in G93A SOD1 mice is affected by levels of neuronal MT-III expression at an early symptomatic time point. *p < 0.03.n = 4 for each group.