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. 2002 Jun 15;22(12):5204–5209. doi: 10.1523/JNEUROSCI.22-12-05204.2002

Fig. 2.

Fig. 2.

Blockade of ARs impaired spatial learning and memory in male apoE4 but not apoE3 mice. Six-month-old male NSE–apoE4 and NSE–apoE3 mice (n = 6–7 mice per genotype and treatment) were tested in the water maze during AR blockade with hydroxyflutamide (see Materials and Methods). A, Hydroxyflutamide impaired learning in the hidden-platform sessions in apoE4 mice (p < 0.05 vs vehicle-treated apoE4 mice; repeated-measures ANOVA) but not in apoE3 mice.B, Hydroxyflutamide impaired retention of spatial memory in apoE4 but not apoE3 mice. *p < 0.05 versus any other quadrant (Tukey–Kramer test).