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. 2002 Jun 15;22(12):5204–5209. doi: 10.1523/JNEUROSCI.22-12-05204.2002

Fig. 3.

Fig. 3.

ApoE4 impairs object-recognition memory in female mice. Novel-object recognition was tested in untreated 6-month-old male (M) and female (F) mice. The results shown are from the memory-retention session.A, NSE–apoE4 (11 males, 7 females) and NSE–apoE3 (4 males, 7 females) mice. B, Wild-type (Wt) (11 males, 6 females) and Apoe−/− (7 males, 13 females) mice. C,Apoe−/− (6 females) and GFAP–apoE4 (6 females) mice. Most mice showed normal object-recognition memory. Only female mice that expressed apoE4 in neurons (A) or astrocytes (C) failed to spend significantly more time with the novel than with the familiar object. °p < 0.05; *p < 0.01 versus time exploring the familiar object (Tukey–Kramer test); n.s., not significant.