Fig. 4.

Cytosolic AR levels in the neocortex and response to androgen treatment. Total cytosolic AR levels were determined from AR saturation curves using a single curve-fit analysis. Results are expressed as femtomoles of [³H]R1881 bound per milligram of protein. There were no differences inK_d among the groups (data not shown).A, Untreated male and female NSE–apoE4 mice had lower cytosolic AR levels than untreated NSE–apoE3,Apoe^−/−, and wild-type (Wt) mice (n = 3–7 mice per gender and genotype). B–D, Effect of placebo (B), testosterone (C), and dihydrotestosterone (D) on AR saturation curves in female NSE–apoE4 mice (n = 3–6 mice per treatment).