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. 2002 Jun 15;22(12):5034–5041. doi: 10.1523/JNEUROSCI.22-12-05034.2002

Fig. 5.

Fig. 5.

In P21–P25 rats, bath application of FK506 restored agonists-induced group II mGluR-dependent LTD. The figure shows averaged field potential recordings. The initial slopes of field EPSPs were normalized to the baseline value preceding the induction of LTD. Each data point represents mean ± SEM.A, Bath application of trans-ACPD (hatched bars) resulted in transient depression of field EPSPs but not in LTD. In the same slices, however, the same concentration of trans-ACPD in the presence of FK506 (black bar) resulted in LTD (n = 6).B, Bath application of l-CCG-1 (hatched bars) resulted in transient depression of field EPSPs but not in LTD. In the same slices, however, the same concentration of l-CCG-1 in the presence of FK506 (black bar) induced LTD (n = 6).