Absence of ubiquitinated deposits and astrocytosis in Thy1-SOD1(G93A) mice. The data are from Thy1-SOD1(G93A) line 13 mice, but similar results were obtained with the other Thy1-SOD1(G93A) lines and with Thy1-SOD1(G85R) lines. A, Ubiquitin immunoreactivity in lumbar spinal cord (ventral horn). Thearrows point to ubiquitin-positive inclusions; theinset shows a large neuron with inclusions.B, GFAP-positive astrocytes (arrows) in lumbar spinal cord (ventral horn). Scale bar: A, 40 μm; B, 100 μm.