Fig. 10.

ER-X is upregulated after ischemic brain injury in the adult. Comparison of ER-α and ER-X expression in the infarcted and noninfarcted adult neocortex. After a large ischemic infarct in the neocortex produced by middle cerebral artery occlusion, there was not only upregulation of ER-α expression in the penumbra of the ligated, ischemic side but also upregulation of ER-X therein as well, suggesting re-expression of a developmental mechanism normally latent in the adult. Note the lack of significant ER-X expression on the noninfarcted side. MCF-7 mammary tumor cells and adult uterus = ER-α controls; P7 neocortex = ER-X control.