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. 2002 Oct 1;22(19):8438–8446. doi: 10.1523/JNEUROSCI.22-19-08438.2002

Fig. 5.

Fig. 5.

Effect of the D232N and D238N mutations on short-term synaptic plasticity analyzed in cultured hippocampal neurons. A, Average synaptic currents (EPSCs) recorded from “microisland” cultures in response to 10 Hz stimulation. EPSCs are normalized to the first response; top traces show a comparison of D232N mutant neurons with wild-type (WT) neurons, and bottom traces show a comparison of D238N mutant neurons with wild-type neurons. Stimulus artifacts areblanked. B, Plot of the average EPSC amplitudes normalized to the first response recorded during 10 Hz stimulation. The comparison of D232N mutant with wild-type responses is shown on the left, and the comparison of D238N mutant with wild-type responses is shown on the right.C and D are same as A andB but with 50 Hz stimulation.