Fig. 7.
The ACPD-induced priming effect is deficient in Gαq mutant mice. A, Bath application of ACPD (20 μm, 10 min, horizontal bars) enhanced the subsequent LTP induced by the weak TBS of three trains (downward arrow) in wild-type mice (control,n = 6; ACPD, n = 7).B, A TBS of five trains (downward arrow) induced LTP in Gαq mutant mice (control, n = 6). Bath application of ACPD (20 μm, 10 min,horizontal bars) did not enhance LTP (ACPD,n = 6). C, The average increase in initial slopes of fEPSPs (50–60 min after TBS). ∗∗p < 0.01.