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. 2002 Nov 15;22(22):9912–9921. doi: 10.1523/JNEUROSCI.22-22-09912.2002

Fig. 2.

Fig. 2.

A, Ipsilateral BLA priming is mediated by NE and CORT but not by 5-HT. Priming the BLA in NE-depleted (DSP-4 Ipsi Priming, n=12) or CORT-depleted (Met Ipsi Priming, n=7) rats did not enhance DG-LTP as seen in the Ipsi BLA Priming group (+30 min: DSP-4 Ipsi Priming, *p < 0.0001; Met Ipsi Priming, p < 0.01; +60 min: DSP-4 Ipsi Priming, *p < 0.0001; Met Ipsi Priming, p < 0.001). This suggests that both NE and CORT may mediate the BLA priming enhancing effect on hippocampal LTP. In contrast, priming the BLA in 5-HT-depleted rats (PCPA Ipsi Priming, n=7) enhanced DG-LTP as in the Ipsi BLA Priming group, and this group was significantly different from the other depleted groups at both +30 min (DSP-4 Ipsi Priming, *p < 0.01; Met Ipsi Priming, p < 0.01) and +60 min post-HFS (DSP-4 Ipsi Priming, *p < 0.0001;Met Ipsi Priming, p < 0.01). This suggests that the BLA priming enhancing effect on DG-LTP is not dependent on serotonergic activation. B, Schematic drawings of BLA electrode placements. Solid black circles indicate the locations: (1) DSP-4 Ipsi Priming group, (2) Met Ipsi Priming group, and (3) PCPA Ipsi Priming group.