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. 2002 Nov 15;22(22):10039–10045. doi: 10.1523/JNEUROSCI.22-22-10039.2002

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Fig. 2. — Effect of cocaine administration on locomotion.a, Distance traveled during the first hour after cocaine injection. A 2 × 4 ANOVA for dose and genotype revealed a significant effect of dose (F_(3,117) = 67.3; p < 0.0001) and genotype (F_(1,117) = 14.9; p< 0.001) but no interaction. Also shown is distance traveled during 5 min bins on day 4 with 0 (b), 7.5 (c), 15 (d), and 30 (e) mg/kg cocaine given by intraperitoneal injections at 120 min. The peak locomotion values for the 5-HT2C receptor mutants were significantly different from those of the WT mice (F_(1,117) = 8.2; p= 0.005) and increased significantly with dose (F_(3,117) = 85.7; p< 0.0001) without an interaction of dose and genotype.