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. 2002 Nov 15;22(22):9932–9940. doi: 10.1523/JNEUROSCI.22-22-09932.2002

Fig. 5.

Fig. 5.

LTP at 5 Hz distinguishes between slices from AI and AU rats. A, AI slices subjected to 5 Hz, 30 sec stimulation exhibited significantly smaller synaptic potentiation in CA1 than that seen in either young or AU slices [Y,n = 17(8); AU, n = 20(7); AI,n = 32(13)]. ***p < 0.001 compared with young and AU. B, All groups responded to 5 Hz stimulation with a similar time course and number of complex spikes.Inset in B shows a representative set of traces collected during 30 sec of 5 Hz stimulation in a young slice. Calibration: 1 mV, 10 msec. C, Slices taken from the contralateral hippocampus of a subset of animals in Awere subjected to three 0.5 sec trains at 30 Hz stimulation. The resulting LTP in both AU and AI slices was smaller than that in young controls (p < 0.05), but no AU–AI difference was detected [Y, n = 17(14); AU,n = 11(6); AI, n = 8(5)].D, Stimulation at 70 Hz in a separate set of rats induced robust, long-lasting, and statistically equivalent LTP in all groups [Y, n = 13(11); AU, n = 17(9); AI, n = 8(7)]. Data pointsin C and D are presented at 5 min intervals for clarity.