Fig. 4.

Morphological analysis of the adult p73−/− brain. a, Top two panels, Photographs of p73+/+ versus p73−/− brains. Brains were photographed on top of a light box to show the translucency of the p73−/− cortex.a, Bottom two panels, Photographs of Nissl-stained coronal sections from representative p73+/− and p73−/− brains. The p73−/− section derives from the brain shown in thetop right panel. b, Photographs of Nissl-stained coronal sections through the forebrain of four p73−/− brains. For comparison, the top panel is a coronal section at a similar level from an adult p73+/+ brain. Themiddle three brains were classified as severely affected (as was that shown in a), whereas the right bottom panel was classified as moderately affected.c, Photomicrograph of the Nissl-stained cortex from a p73+/+ versus p73−/− brain at the lateral level. Scale bar, 150 μm.