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. 2002 Nov 15;22(22):9922–9931. doi: 10.1523/JNEUROSCI.22-22-09922.2002

Fig. 6.

Fig. 6.

Comparison of the magnitude and time course of inhibition in the three strains. A, Calculated total charge transfer (holding potential, −60 mV; Cl− reversal potential, ∼0 mV) for averaged mIPSCs in various subpopulations, as described in Materials and Methods and shown in Figure 1. For normal and seizure-resistant strains, data shown are pooled between pyramidal (Pyr) and nonpyramidal (Non-Pyr) neurons. Despite differences in the peak amplitude of mIPSCs between the strains, there were no significant differences in the total charge transfer. B, Plot of deviations of average mIPSCs of the same subpopulations as above from the time course of the average mIPSC in normal rats. Data are presented as a percentage of the peak amplitude of the average mIPSC in normal rats. Inhibitory synapses in seizure-resistant (SR) rats pass more charge than those in normal rats over the first 10–20 msec. Synapses of seizure-prone (SP) rats, conversely, pass up to 50% less charge over the same time period compared with normal rats. These differences are compensated over the succeeding 100 msec to yield no net differences in charge transfer.