Table 1.
Comparison of mIPSCav attributes in morphologically identified neurons of seizure-resistant, normal, and seizure-prone rat strains
Strain, cell type | |||||||
---|---|---|---|---|---|---|---|
Seizure-resistant | Normal | Seizure-prone | |||||
Pyramidal | Nonpyramidal | Pyramidal | Nonpyramidal | Pyramidal | Nonpyramidal | ||
Number of cells | 15 | 12 | 15 | 9 | 15 | 12 | 41-b |
τ1(msec) | 1.7 ± 0.13* | 1.6 ± 0.1 | 2.4 ± 0.2 | 2.1 ± 0.2 | 3.0 ± 0.7* | 5.1 ± 0.51-165 | |
τ2 (msec) | 20.3 ± 1.01-165 | 21.0 ± 0.8 | 24.2 ± 2.5 | 24.3 ± 2.4 | 27.7 ± 3.4* | 39.9 ± 5.21-165 | 26.6 ± 6.7 |
% τ11-a | 40.0 ± 5.1 | 30.0 ± 2.9 | 40.0 ± 2.5 | 30.0 ± 6.7 | 40.0 ± 2.5 | 46.7 ± 4.5 | |
Amplitude (pA) | −57.3 ± 4.01-165 | −59.8, 3.6* | −44.6 ± 3.7 | −51.7 ± 5.2 | −39.7, 3.8 | −34.0 ± 4.1* | −29.4 |
Values are mean ± SEM.
Percentage of deactivation time course devoted to fastest time constant.
Neurons identified as having monoexponentially decaying mIPSCavs.
Significance with respect to neurons of the same morphology in normal rats:
p < 0.05;
F1-160: p < 0.01;
F1-165: p< 0.001.