Table 2.
Strain, cell type | ||||||
---|---|---|---|---|---|---|
Seizure-resistant | Normal | Seizure-prone | ||||
Pyramidal | Nonpyramidal | Pyramidal | Nonpyramidal | Pyramidal | Nonpyramidal | |
Number of cells | 13 | 12 | 13 | 9 | 13 | 11 |
Monoexponential | ||||||
τ1 (msec) | 11.6, 14.32-160 | 12.1, 13.02-160 | 14.4, 15.9 | 15.7, 17.1 | 17.1, 18.8**,*** | 21.6, 23.4**,*** |
Amplitude (pA) | −39.9, 35.02-160 | −39.0, 27.1* | −32.7, 25.8 | −35.9, 23.4 | −26.3, 24.6**,*** | −27.8, 17.0**,*** |
Number of events | 750 | 533 | 634 | 500 | 560 | 534 |
Biexponential | ||||||
τ1 (msec) | 1.7, 0.8* | 1.6, 0.7 | 2.3, 1.1 | 1.7, 0.8 | 2.6, 1.12-165 | 4.4, 1.5**,*** |
τ2 (msec) | 26.3, 9.82-160 | 25.8, 9.4 | 35.0, 12.9 | 31.5, 10.8 | 35.8, 12.62-165 | 51.6, 20.1**,*** |
% τ1 | 42.4, 11.9 | 41.3, 11.7 | 42.9, 11.5 | 35.2, 9.9 | 43.6, 10.5 | 44.9, 10.12-160 |
Amplitude (pA) | −74.1, 43.62-160 | −60.3, 18.9 | −49.3, 13.8 | −56.0, 15.4 | −43.1, 24.72-165 | −36.2, 14.5**,*** |
Number of events | 200 | 163 | 189 | 149 | 187 | 157 |
Values are median, interquartile range.
Percentage of deactivation time course devoted to fastest time constant.
Significance with respect to neurons of the same morphology in normal rats:
p <0.01;
F2-160: p<0.001.
Significance with respect to neurons of the same morphology in seizure-resistant rats:
F2-165: p ≪0.001.