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. 2002 Aug 15;22(16):6900–6907. doi: 10.1523/JNEUROSCI.22-16-06900.2002

Fig. 2.

Fig. 2.

Cannabinoids reduce the frequency of glutamatergic sEPSCs in striatal spiny neurons of naive and parkinsonian (6-OHDA) rats. A–D, Cumulative probability plots of glutamatergic sEPSCs recorded from single striatal neurons of naive (left) and a 6-OHDA-lesioned (right) rats. Electrophysiological traces show spontaneous striatal glutamatergic activity before (top) and after (bottom) drug administration. Application of 1 μm HU-210 (A) reduces significantly sEPSCs frequency (expressed as interevent interval) in both neurons (p < 0.01 for both; KS test). A similar effect is obtained with 10 μm AM-404 (B) in both naive (p< 0.05; KS test) and 6-OHDA-lesioned (p < 0.01; KS test) animals. Conversely, 10 μm PMSF (C) is ineffective on the naive neuron (p > 0.05; KS test) but reduces sEPSC frequency (p < 0.01; KS test) in the 6-OHDA-lesioned cell. Similarly, 25 nm MAFP was effective in decreasing sEPSC frequency only in the cell from a parkinsonian rat (p < 0.01; KS test) but not in the naive one (p > 0.05; KS test).