Fig. 5.

Specific activation of CB1 receptor reduces sEPSC frequency. A, Activation of CB1 receptor by AEA reduced glutamatergic spontaneous activity in spiny neurons from both naive and 6-OHDA-lesioned rats (*p < 0.01; ST test;n = 4 for each condition). A low dose of PMSF was added to anandamide to avoid the rapid degradation by endogenous FAAH (see Results for details). B, The histogram shows that blockade of CB1 receptor by 1 μm SR-141716 prevents the inhibitory action of AM-404 or PMSF, whereas blockade of VR1 vanilloid receptor has no effect (*p < 0.01; ST test; n = 4 for each condition).