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A proposed model for the role of GFAP phosphorylation. GFAP phosphorylation may play a dual role. The phosphorylation protects GFAP from proteolysis and contributes to shift soluble-filament equilibrium to the left. The larger pool of soluble subunits protected by phosphorylation and partial depolymerization of filamentous subunits triggered by phosphorylation will synergistically accelerate the structural plasticity of glial filaments.
