Fig. 2.
Acute dopamine D1-class and D2-class receptor agonist treatments induce varying levels of early-gene expression in striosomes and matrix of the striatum. Values indicate net deviations from baseline levels of Fos expression in striosome and matrix compartments compared with values in saline-treated animals. Baseline values were as follows: medial matrix, 30.50 ± 9.51; medial striosomes, 39.60 ± 16.42; lateral matrix, 2.78 ± 1.32; and lateral striosomes, 3.81 ± 1.6. Of the single agonist challenges (black bars), only SKF 81297 induced significant levels of Fos expression in the striatum. Activation in the striosomes was much greater than activation in the matrix when increasing doses of quinpirole were combined with 1 mg/kg (hatched bars) or 3 mg/kg (white bars) SKF 81297. ANOVA indicated a significant high-order interaction of agonist × sector × compartment (F(6,42) = 3.113; p< 0.013). Quin, Quinpirole; SKF, SKF 81297.