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Representative phrenic neurogram taken before, during, and 1 hr after intermittent hypoxia in rats pretreated with artificial CSF (A), methysergide (B; 250 μg/kg), or emetine (C; 1 μg/kg). In all rats, the integrated phrenic amplitude returned close to baseline levels immediately after intermittent hypoxia. Only rats pretreated with artificial CSF had a subsequent progressive increase in phrenic amplitude over the course of the next hour, indicating phrenic long-term facilitation.
