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. 2002 Jul 15;22(14):6052–6061. doi: 10.1523/JNEUROSCI.22-14-06052.2002

Fig. 6.

Fig. 6.

A, Mean frequency of stages 4–6 seizures per week over the 20 week period after a single pilocarpine injection (1Pilo) and two KA plus one pilocarpine injections (2KA–1Pilo) in Fischer-344 rats. Starting from week 9, there were a significant group effect (F(1,6) = 17.229; p< 0.05) and a significant interaction of groups over time (F(3,6) = 28.806; p< 0.001) in the frequency of stages 4–6 seizures between 1Pilo and 2KA–1Pilo groups. B, Neuronal loss and mossy fiber sprouting (MFS) in Fischer-344 rats receiving 1Pilo, 2KA–1Pilo, and saline injections in Fischer-344 rats. Neuronal loss and mossy fiber sprouting were quantified using the same protocols as those in Figure 5.